Any time I see an article or a study about osteoarthritis I check it out because as we all know -- my arthritic knee has caused me no end of grief. I thought this study in particular was surprising. Ozone?! Interesting. It was published on Medscape Medical News. Check it out.
Ozone Injections Promising in Knee Osteoarthritis
November 13, 2015
SAN FRANCISCO — An ozone injection into the knee can soothe pain and improve quality of life for people with knee osteoarthritis, a randomized controlled trial suggests.
"When I saw the results I was very surprised," said Virginia Fernandes Moça Trevisani, PhD, from the Federal University of Sao Paulo, who presented the finding here at the American College of Rheumatology (ACR) 2015 Annual Meeting.
Ozone appears to inhibit prostaglandins and cytokines and reduce oxidative stress, she told Medscape Medical News.
It has been used in Europe for many years in the treatment of cancer, AIDS, caries, rheumatoid arthritis, and a variety of other ailments. However, it is not approved for clinical use in Brazil or in the United States, and the only studies in osteoarthritis have been case reports, Dr Trevisani explained.
She said she was skeptical when she read the literature. "It seemed too good to be true."
To test the claims, Dr Trevisani and her colleagues recruited 98 people 60 to 85 years of age who met the ACR criteria for knee osteoarthritis.
The researchers randomized 63 patients to an injection of ozone gas 10 mL once a week for 8 weeks, and randomized 35 patients, who served as the control group, to injections of air......
....The results are surprising, said James Udell, MD, from the Arthritis Group in Philadelphia, who moderated the press conference that was held after an ACR team flagged the study as one of the most interesting abstracts being presented.
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