Friday, July 26, 2013


Yesterday's post just proves once again that a foggy Julia should not attempt a task any more complicated than operating a can opener.

Because as I've mentioned before, for me, TIRED = STUPID.

In writing about the baminercept studies, I was lazy and copied and pasted information about this drug without doing multiple fact checking and mis-identified it as a TNF inhibitor.


I'm thankful to Dr. Carterton for pointing out my error. I have since corrected my post.

Baminercept actually is a dual-mechanism, lymphotoxin-b (LT-b) and LIGHT pathway inhibitor.

(I know. I said the same thing when I read it. It's complicated.)

Here's where I goofed. Image and text found here:

Fig. 1. The tumor necrosis factor (TNF) core family and signaling pathways. The interactions of TNF cytokines with their cognate receptor(s) are shown by arrows. Binding of ligand to receptor leads to the induction of downstream signaling cascades. The presence of a DD in the intracellular portion of the receptor (depicted in yellow) results in the recruitment of TNF receptor 1 (TNFR1)-associated death domain (TRADD) and the ultimate induction of apoptosis. In the absence of a DD, TNFRs interact directly with TNF receptor-associated factor (TRAF) molecules to induce signaling via the classical nuclear factor kB (NFkB) pathway, resulting in the translocation of NFkB heterodimers (i.e. p50/RelA) to the nucleus to induce effector genes. The LTbR also induces
a nonclassical NFkB pathway involving the processing of p100 and the translocation of p52/RelB to the nucleus. HVEM, HSV entry mediator; FADD, Fas-associated death domain; IKK, IkB kinase; NIK, NFkB-inducing kinase.

So I made the assumption that since lymphotoxin-beta receptor ( LTBR ) is a member of the tumor necrosis factor receptor superfamily (TNF), that this drug when it suppressed LTBR would also be considered a TNF inhibitor. But this assumption is wrong because it's too generalized.

In the future, all posts written by me on brain foggy days will be about stuff Cute kittens. Adorable puppies. I'll wah-wah-wah about things and talk about junk that I've bought on Amazon. But I won't take on tasks which require more than three functioning brain cells.

I promise.


Amy Junod said...

That chart makes my brain hurt.

Julie said...

Julia, you always put a smile on my face, while also providing important info, and also posting some soul refreshing pics and stories! Thanks for helping us all be the best patient advocates we can all be, for ourselves, and for our fellow sufferers, as well!